VACCINATION
NEWSFLASH
I would like to make you aware
that all 27 veterinary schools in North America are in the
process of changing their protocols for vaccinating dogs
and cats. Some of this information will present an ethical
& economic challenge to vets, and there will be skeptics.
Some organizations have come up with a political compromise
suggesting vaccinations every 3 years to appease those who
fear loss of income vs those concerned about potential side
effects. Politics, traditions, or the doctor's economic
well being should not be a factor in medical decision. NEW
PRINCIPLES OF IMMUNOLOGY "Dogs and cats immune systems
mature fully at 6 months. If a modified live virus vaccine
is given after 6 months of age, it produces an immunity
which is good for the life of the pet (ie: canine distemper,
parvo, feline distemper). If another MLV vaccine is given
a year later, the antibodies from the first vaccine neutralize
the antigens of the second vaccine and there is little or
no effect. The titer is not "boosted" nor are
more memory cells induced. "Not only are annual boosters
for parvo and distemper unnecessary, they subject the pet
to potential risks of allergic reactions and immune-mediated
hemolytic anemia. "There is no scientific documentation
to back up label claims for annual administration of MLV
vaccines "Puppies receive antibodies through their
mothers milk. This natural protection can last 8-14 weeks.
Puppies & kittens should NOT be vaccinated at LESS than
8 weeks. Maternal immunity will neutralize the vaccine and
little protection (0-38%) will be produced. Vaccination
at 6 weeks will, however, delay the timing of the first
highly effective vaccine. Vaccinations given 2 weeks apart
suppress rather than stimulate the immune system. A series
of vaccinations is given starting at 8 weeks and given 3-4
weeks apart up to 16 weeks of age. Another vaccination given
sometime after 6 months of age (usually at 1 year 4 mo)
will provide lifetime immunity. CURRENT RECOMMENDATIONS
FOR DOGS
"Distemper & Parvo.
According to Dr. Schultz, AVMA, 8-15-95, when a vaccinations
series given at 2, 3 & 4 months and again at 1 year
with a MLV, puppies and kitten program memory cells that
survive for life, providing lifelong immunity. "Dr.
Carmichael at Cornell and Dr. Schultz have studies showing
immunity against challenge at 2-10 years for canine distemper
& 4 years for parvovirus. Studies for longer duration
are pending. "There are no new strains of parvovirus
as one mfg. would like to suggest. Parvovirus vaccination
provides cross immunity for all types. "Hepatitis (Adenovirus)
is one of the agents known to be a cause of kennel cough.
Only vaccines with CAV-2 should be used as CAV-1 vaccines
carry the risk of "hepatitis blue-eye" reactions
& kidney damage. "Bordetella Parainfluenza: Commonly
called "Kennel cough", recommended only for those
dogs boarded, groomed, taken to dog shows, or for any reason
housed where exposed to a lot of dogs. The intranasal vaccine
provides more complete and more rapid onset of immunity
with less chance of reaction. Immunity requires 72 hours
and does not protect from every cause of kennel cough. Immunity
is of short duration (4 to 6 months). RABIES
There have been no reported cases of rabid dogs or cats
in Harris, Montogomery or Ft. Bend Counties [Texas], there
have been rabid skunks and bats so the potential exists.
It is a killed vaccine and must be given every year. Lyme
disease is a tick born disease which can cause lameness,
kidney failure and heart disease in dogs. Ticks can also
transmit the disease to humans. The original Ft. Dodge killed
bacteria has proven to be the most effective vaccine. Lyme
disease prevention should emphasize early removal of ticks.
Amitraz collars are more effective than Top Spot, as amitraz
paralyzes the tick's mouth parts preventing transmission
of disease.
VACCINATIONS NOT RECOMMENDED Multiple components in vaccines
compete with each other for the immune system and result
in lesser immunity for each individual disease as well as
increasing the risk of a reaction.
Canine Corona Virus is only a disease of puppies. It is
rare, self limiting (dogs get well in 3 days without treatment).
Cornell & Texas A& M have only diagnosed one case
each in the last 7 years. Corona virus does not cause disease
in adult dogs. "Leptospirosis vaccine is a common cause
of adverse reactions in dogs. Most of the clinical cases
of lepto reported in dogs in the US are caused by serovaars
(or types) grippotyphosa and bratsilvia. The vaccines contain
different serovaars eanicola and ictohemorrhagica. Cross
protection is not provided and protection is short lived.
Lepto vaccine is immuno-supressive to puppies less than
16 weeks.
AS above, this may have caused
my puppies disease.
Steve
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Vaccination:
Which ones do they REALLY NEED, and HOW OFTEN?
by Ann Brightman
When Helena took her new Sheltie puppy, Mick, to the vet
for his first check-up, she felt more than a little anxious
when it came time for him to receive his shots. While she
wanted to protect her new friend from deadly diseases like
distemper and parvo, she was also concerned about the health
risks associated with over-vaccination. Although Helena
went ahead with the vaccines and follow-up boosters, she
was worried about subjecting Mick to subsequent annual shots,
even though her vet told her she was risking her dog’s
health even more by not doing so.
It’s a common quandary these days,
especially as we hear more and more about the often devastating
side effects of over-vaccination. How do we prevent our
dogs or cats from contracting infectious diseases that can
often be fatal, while also protecting them from the equally
serious health consequences of too many shots? The best
strategy is to learn which vaccines are absolutely necessary
(referred to as core vaccines), why they’re needed,
and what the minimum requirements are for each to ensure
protection from disease without over-vaccinating.WHAT ARE CORE VACCINES?
“Core vaccines are those that every dog or cat should
receive, regardless of geographic location or lifestyle,”
says Dr. Ron Schultz, Professor and Chair of the Department
of Pathological Studies at the University of Wisconsin-Madison’s
School of Veterinary Medicine. For dogs, the four core vaccines
are canine distemper (CDV), canine parvovirus-2 (CPV-2),
canine adenovirus-2 (CAV-2) and rabies. Those for cats are
feline panleukopenia or parvovirus (FPV), feline herpesvirus-1
(FHV-1), also referred to as feline viral rhinotracheitis,
feline calicivirus (FCV) and rabies. In this article, the
first in a three-part series, we’ll be taking a close-up
look at canine distemper, feline panleukopenia and rabies.The eight vaccinations listed above are
considered core because the diseases they protect against
are distributed over a wide area and have a high mortality
rate. “These vaccinations are absolutely necessary,”
says Dr. Schultz. “You want the vaccine to be the
first antigens to prime the immune system. You don’t
want to leave it up to natural immunization or exposure.”
This is because, when compared to the actual disease-causing
virus, the vaccine is a safer way to protect the animal.
“If the vaccine is live, it’s attenuated. If
it’s killed, it can’t cause disease,”
explains Dr. Schultz. “It’s true that many puppies
that never see a vet get naturally immunized by exposure
to distemper, as an example, but for every one that gets
vaccinated, probably another would have died if the first
encounter with distemper occurred prior to vaccination.”MINIMIZING VACCINATION
Although core vaccines are necessary to protect your companion
from infectious disease, even these do not need to be given
on an annual basis. “That’s what we’re
trying to change,” says Dr. Schultz. “What we
recommend is that both puppies and kittens get the core
vaccines at least once at or over the age of 12 weeks.”
The 12 weeks is significant, because prior to that, many
animals still have passive maternal antibodies that block
immunization, which means they may not respond to the vaccine
and are therefore unprotected against the disease. American
Association Hospital Association (AAHA) guidelines recommend
vaccinating again at one year, and once every three years
after that, although even that may not be necessary. “I
have studies that show duration of immunity at seven to
nine years for all the core vaccines except rabies, and
even on an antibody basis I can show that rabies gives much
longer protection than three years,” says Dr. Schultz.CANINE DISTEMPER (CDV)
CDV is a highly infectious and often fatal disease that
attacks the respiratory, gastrointestinal and central nervous
systems. Although dogs of any age can contract distemper,
puppies up to six months of age are most susceptible to
the disease, which
can cause a range of symptoms from fever, loss of appetite
and eye inflammation in its early stages, to diarrhea, vomiting,
pneumonia, and neurological complications such as ataxia,
seizures and paralysis.Canine distemper occurs around the world
not only among domesticated dogs, but also in many wild
carnivores such as raccoons, skunks and foxes. “Wildlife
is actually now more of a reservoir for distemper than dogs
are,” says Dr. Schultz. “The virus is spread
mainly by air, or by direct contact with secretions from
the infected animal. The mortality rate among puppies with
distemper is 50% or higher.” On the plus side, the
distemper virus is very fragile and easily destroyed by
outside influences. “It doesn’t live very long
in the environment,” says Dr. Schultz. “It dies
very quickly because it is what we call an enveloped virus.
These kinds of viruses are highly susceptible to water,
disinfectant and sunlight.”Although there is only one distemper serotype,
there are several genotypes. “What this means is that,
from an immunologic standpoint, it doesn’t matter
which distemper infects the animal, they’re all similar;
the vaccine for canine distemper can protect against the
different genotypes.” Dr. Schultz adds that modified
live vaccines (MLV) are most effective for distemper. “In
fact there’s no question in my mind that you should
be using live vaccines for most of the cores. Although attenuated,
live vaccines infect and replicate, and that’s how
you get immunity.”Although AAHA recommends vaccinating against
distemper every three years after the initial puppy shots,
challenge studies have shown that the minimum duration of
immunity can last five to seven years, and perhaps even
longer. In fact, titers have indicated that dogs can be
protected for nine to 15 years. “To be honest, although
canine distemper is a core vaccine, I think a dog only needs
to receive it once in his life,” says Dr. Schultz.
“The same goes for canine parvo and adenovirus-2.
That’s the vaccination program I’ve been practicing
on my own dogs without any difficulty whatsoever. We’ve
never had a vaccine-preventable disease occur.”Titer testing is highly effective for canine
distemper, but according to Dr. Schultz, the best time to
do it is at two weeks or more after the last puppy vaccination,
to ensure that the animal responded to its initial vaccines.
“To my mind, that’s the only time it’s
of medical benefit to use a titer test for canine distemper.
After that, you don’t really need to titer the animal
since you can easily go five or seven years before the next
vaccine.”FELINE PANLEUKOPENIA (FPV)
Although FPV is sometimes referred to as feline distemper,
this terminology is misleading. “When I talk about
feline ‘distemper,’ I always talk about it as
feline parvo or panleukopenia,” explains Dr. Schultz.
“The virus that causes this disease is essentially
identical to the canine parvo virus, but not the canine
distemper virus. If a dog has parvo, it can infect a cat,
but this doesn’t happen with distemper.”Most often found in kittens, FPV is a contagious
and deadly disease that attacks and destroys growing cells
in the intestine, blood and nervous system. It causes diarrhea,
vomiting, a lowered white blood cell count, and neurological
symptoms such as tremors. Kittens up to six months of age
can easily die from the disease, while older cats may develop
much milder signs. “There’s a tremendous age-related
resistance to parvo,” says Dr. Schultz. “If
the animal is less than a year old, mortality is 80% to
100%. However, I rarely see mortality in animals over a
year of age, although I might see mild morbidity. Nevertheless,
feline parvo is the one cat vaccin4e I absolutely insist
on.”Like canine distemper, feline parvo has
worldwide distribution with outbreaks occurring most commonly
in urban areas during the summer months. The disease is
transmitted by direct contact, although cats can also contract
FPV from the fecal matter of an infected feline. Unlike
canine distemper, the parvo virus is extremely long-lived,
and can remain active in the environment for months or even
longer. “Parvo is what we call a naked virus and is
one of the most resistant,” says Dr. Schultz. Soil
contaminated with the parvo virus still has the ability
to infect an animal a year later. “In fact, parvo
is more often caused by environmental contamination than
direct contact with an infected animal. You don’t
need the infected cat to be in the environment for very
long in order for it to leave the virus behind.”As with canine distemper, MLV vaccines are
very effective for preventing feline panleukopenia. “With
parvo, in fact, you’d better be using live vaccines,
because the killeds don’t work.” As with other
core vaccines, kittens should be vaccinated at 12 weeks.
Titer testing is very effective for this disease, although
challenge studies indicate that a vaccinated kitten can
remain protected from feline parvo for eight years.RABIES (RV)
Unlike distemper and parvo, rabies is a disease that can
be transmitted from animals to humans, which is why rabies
vaccinations are required by law throughout North America.
The virus infects the central nervous system, causing encephalitis
and death. Symptoms can include confusion, partial paralysis,
aggressive behavior, excessive salivation and other neurological
signs. Although rabies occurs worldwide, including in Asia,
Africa and Latin America, some countries such as the U.K.
are rabies-free. In North America, rabies is most prevalent
in the eastern portions of the continent, although cases
can occur anywhere. Wild animals such as raccoons, skunks,
bats and foxes are the major carriers. Because rabies isn’t
age-related, mammals at all stages of life can be affected
with the same degree of severity. The chief means of transmission
is by a bite from an infected animal.“There are multiple strains of rabies,
but the important thing is that the vaccine prevents infection
with all those different strains,” says Dr. Schultz.
“Although the risk of infection in domesticated animals
is generally low, the public health concern is the issue.
That’s what drives the regulations for rabies vaccines.”
As with the other core vaccines, puppies and kittens should
be vaccinated at 12 weeks. Although some states and provinces
have approved a three-year rabies vaccine, some still require
annual re-vaccination for dogs and cats, even though the
duration of immunity based on challenge studies has been
shown to be three to seven years. “The regulations
vary from state to state and province to province, and even
from municipality to municipality.” It’s also
important to realize that a municipality might have a more
restrictive requirement than the state or province it’s
a part of, although not the other way around.“Rabies titers are effective, but
there’s no point running them because you’re
going to have to vaccinate your animal by law anyhow,”
says Dr. Schultz. However, titer testing for rabies is useful
in cases where the animal has had an adverse reaction to
the vaccine, or has a medical condition that could be aggravated
by the vaccination. “In these situations, local municipalities
will sometimes accept a letter from the vet as a reason
not to vaccinate every three years, But the guardian has
to understand that the animal is still considered to be
non-vaccinated, and if it bit someone, it would be treated
as such if it’s gone beyond the three years, irrespective
of the vet’s letter. Even so, if you have a dog that
for health reasons
shouldn’t be given a rabies vaccine, it’s better
to take the chance of it being quarantined for biting someone
than to give the vaccine and kill the dog.”
BACK TO BASICS
Vaccinations definitely have their place in disease prevention,
but knowing where to draw the line is key. “I’ve
seen it go from no vaccines back in the mid-1960s, to where
we just kept adding one after the other,” says Dr.
Schultz. The pendulum has since started swinging back again
as organizations such as AAHA and American Association of
Feline Practitioners (AAFP) began looking more closely at
which vaccines out of the 12 for cats and 16 for dogs were
really needed and why. “We used to have one manufacturer
that made a canine vaccine combo with 13 different components
in it. That’s not good, and that’s why it’s
not available anymore.” Now, by contrast, companies
are coming out with information demonstrating that their
products give duration of immunity lasting several years.
“All the major manufacturers are coming on board and
saying that their core vaccines give at least three years
immunity. To me, that’s the greatest gratification
in the more than 25 years I’ve been doing this.” |